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Research Description:
We are interested in chromosome dynamics. We want to know how genes are
packaged and unpackaged, how chromatin structure regulates gene transcription,
and how chromatin misregulation contributes to cancer. We purify large protein
complexes that use ATP hydrolysis or acetylation to remodel chromosomal
structure, and characterize their functions by reconstituting chromatin
remodeling in vitro.
We also apply genetic and genomic (DNA microarray) methods to understand their
functions in vivo
in yeast and human cells.
Research Keywords:
Chromatin, Genomics, Signaling, Transcription